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Generic of gabapentin.) The drug was first approved for the treatment of moderate to severe depression. The new study was led by a team scientists at the University of Alabama Birmingham and published Oct. 26 in the online open-access journal Frontiers in Psychiatry. Using mice lacking genes for neurotransmitters, known as ionotropic glutamate receptors, and the serotonin transporter, researchers determined that the new drug, sertraline, inhibits an new zealand pharmacy online domperidone enzyme in the brain that produces a neurotransmitter called dopamine that is released in response to stress. "This enzyme is the main cause of symptoms that are thought to be linked depression," study leader Dr. Mark M. Olfson, associate director of the UA Orlistat preo comprar Center for Biomedical Research Resources, said in a UA news release. The researchers concluded that "the most likely explanation about why sertraline is effective the effect of this enzyme generic drug gabapentin inhibition on stress that is mediated by serotonin. Since serotonin was the first molecule ever discovered to block the effects of stress (in animals), identifying sertraline as the antidepressant of choice would seem wise," Olfson said, noting that in many cases the new drug "appears to be at least as effective or perhaps more than the FDA-approved antidepressant, fluoxetine (Prozac)" in preventing recurrences of depression. The team also looked at generic to gabapentin effects of sertraline on mice lacking genes for two other neurotransmitters: norepinephrine and dopamine. The authors, who included Dr. Mark Olfson, Thomas Baucom and Dr. Stephen Schapira from the UA Center, found that sertraline inhibited dopamine in the brain and that drug decreased the mice's stress response and increased their levels of an amino acid called tryptophan, which is known to be important for growth. Olfson said the researchers are "now looking at a drug that blocks glutamate receptors in a mouse model of depression, although this is probably a few years away." Another potential drug for depression would be one that was taken orally and had the same side effects as sertraline, Olfson said. The study was funded by University of Alabama at Birmingham and the National Institute of Mental Health by grant R01 MH063715. "It is well known that depression a serious and debilitating illness. Currently, there are limited medications for this serious and debilitating health condition. The authors present a promising new class of compounds targeting the serotonin and gamma-aminobutyric acid systems that have the potential to treat depression and other serious mental illnesses," Martin Shkolnik, professor and director of molecular preclinical pharmacology at the UA College of Pharmacy and Health Sciences, said in the same news release. Read or Share this story: Image copyright Facebook Image caption Naf.

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